I am asked all the time "which anti-inflammatory should I take". Trial and error is often required to choose one of the Non steroidal anti inflammatories (NSAIDS). My first response is always-NONE. But if pain is severe and natural methods are not helping, Ibuprofen (acetaminophen) works to block pain signals by acting on the central nervous system and therefore does not influence the inflammatory pathways, so this would be preferred. Inflammation from tissue injury or autoimmune attack forms prostaglandins that irritates the nerves, leading to pain. Advil, Motrin and Aspirin block the enzyme cyclooxegenase (COX) which dulls the pain but confuses the intricate timing mechanisms necessary for injury repair.  

This article discusses the differences between aspirin, ibuprofen, naproxen and acetaminophen. 

Click on the image to read about this commonly used pain reliever.